Retroviral vector targeting to human immunodeficiency virus type 1-infected cells by receptor pseudotyping.
نویسندگان
چکیده
We report the generation of retroviral vectors based on Moloney murine leukemia virus that specifically transduce cells infected with T-cell-tropic human immunodeficiency virus type 1 (HIV-1). This vector was pseudotyped with T-cell-tropic HIV-1 receptors CD4 and CXCR4. We demonstrate that transduction is contingent upon HIV-1 gp120 and gp41 expression.
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ورودعنوان ژورنال:
- Journal of virology
دوره 74 9 شماره
صفحات -
تاریخ انتشار 2000